Atomoxetine (Strattera): Quick, Practical Guide

Looking for a non-stimulant option for ADHD? Atomoxetine (brand name Strattera) helps many people focus without the stimulant effects of amphetamines or methylphenidate. Below you'll find clear, usable info — how it works, typical dosing, side effects to watch for, and simple safety tips you can use when talking with your doctor.

How atomoxetine works and who it’s for

Atomoxetine blocks the reuptake of norepinephrine in the brain. That boost in norepinephrine can improve attention and reduce impulsivity. Doctors often choose atomoxetine when stimulants aren’t a good fit — for example, if someone has a history of substance misuse, anxiety that worsens with stimulants, or trouble sleeping on stimulant meds. Kids, teens, and adults can all use it, but the dose and monitoring differ by age and weight.

Dosing, side effects, and safety tips

Typical adult dosing starts at 40 mg daily for a few days, then usually moves to 80 mg/day. Many adults find 80–100 mg/day effective. For children and teens dosing is weight-based: a common start is about 0.5 mg/kg/day for a few days, then a target around 1.2 mg/kg/day. The absolute maximum is often 100 mg/day or about 1.4 mg/kg/day in some guidelines. Your prescriber will tailor this for you.

Expect it to take time. Some people notice changes in 2–4 weeks, but full benefit can take 6–8 weeks. If you don’t see improvement, talk to your doctor before changing doses.

Common side effects include upset stomach, decreased appetite, sleep trouble, dry mouth, and dizziness. Less common but serious issues are increased heart rate or blood pressure, liver problems (rare), and mood changes including new or worsening suicidal thoughts in young people. That last risk means parents and caregivers should watch mood and behavior closely, especially in the first few months.

Drug interactions matter. Avoid combining atomoxetine with MAO inhibitors. Strong CYP2D6 inhibitors (like fluoxetine or paroxetine) can raise atomoxetine levels — your prescriber may lower the dose. Tell your doctor about all meds, herbal products, and supplements you use.

Practical tips: take atomoxetine with food to cut down stomach upset; take it at the same time each day; if you split doses, morning and late afternoon works for some people. If you miss a dose, take it when you remember unless it’s close to the next dose — don’t double up. Don’t stop suddenly without checking with your prescriber.

Monitoring usually includes checking blood pressure and heart rate, tracking weight/growth in children, and reporting any sudden mood changes or jaundice. If you’re pregnant, breastfeeding, or planning pregnancy, discuss risks and alternatives — data is limited and choices depend on individual needs.

Want help deciding if atomoxetine fits your situation? Bring this info to your next medical visit and ask about expected benefits, monitoring plans, and whether other options might be better for you.