Cefixime — what it treats and how to use it safely

Cefixime is an oral third‑generation cephalosporin antibiotic. Doctors commonly prescribe it for ear infections, bronchitis, certain cases of urinary tract infection, and some throat infections. It can work well when the bug is sensitive, but it won't help viral illnesses like colds or most sore throats.

How to take cefixime

Typical adult dosing is 400 mg once daily or 200 mg twice daily, depending on the infection. For children, dosing is usually based on weight (about 8 mg/kg per day) with a common maximum around 400 mg daily. Follow your prescriber's instructions exactly.

Take the tablet or suspension with water. You can take it with or without food, but taking it the same way each time helps keep levels steady. Finish the full course even if you feel better after a few days — stopping early can let bacteria survive and become resistant.

Missed a dose? Take it as soon as you remember unless it’s almost time for the next dose. Don’t double up doses to make up for a missed one.

Side effects and safety tips

Most people tolerate cefixime well. Common side effects are diarrhea, nausea, stomach pain, and mild rash. If you get watery or bloody diarrhea after starting it, call your clinician right away — antibiotics can trigger Clostridioides difficile infection, which needs prompt care.

Severe allergic reactions are rare but serious. Stop the drug and seek emergency help if you get trouble breathing, swelling of the face or throat, or a widespread rash with blisters.

Some medicines and substances can change how cefixime works. Antacids, sucralfate, and some acid‑reducing drugs may lower absorption if taken at the same time — separate dosing by a couple of hours. Probenecid can raise cefixime levels by slowing kidney clearance. If you’re on blood thinners, your provider may want closer monitoring because antibiotics can affect clotting in some cases.

Kidney function matters. People with reduced kidney function often need lower doses or longer intervals between doses. If you have kidney disease, check dosing with your provider or pharmacist.

Pregnant or breastfeeding? Cefixime is commonly considered safe in pregnancy, but always run it by your clinician. The same goes for young children: use the pediatric suspension and the exact dose recommended for weight.

Want to avoid resistance? Only use antibiotics when prescribed, take the full course, and avoid saving or sharing leftover pills. If symptoms aren’t improving within 48–72 hours, or if they get worse, contact your healthcare provider — you may need a different drug or further testing like cultures to guide therapy.

Storage is simple: keep capsules or tablets at room temperature, and follow the label for the liquid suspension (some need refrigeration after opening). If you have questions about dosing, side effects, or interactions, your pharmacist can be a quick, reliable source of help.